|Immunohistochemistry (Paraffin) (IHC (P))||10-15 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 16 amino acid peptide from internal region of human SRPX2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BPP; CBPS; PMGX; RESDX; SRPUL; Sushi repeat-containing protein SRPX2; sushi-repeat containing protein, X-linked 2; sushi-repeat protein up-regulated in leukemia; Sushi-repeat protein upregulated in leukemia; sushi-repeat-containing protein; sushi-repeat-containing protein, X-linked 2; X-linked 2
Gene Aliases: BPP; CBPS; PMGX; RESDX; SRPUL; SRPX2
UniProt ID: (Human) O60687
Entrez Gene ID: (Human) 27286
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