|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 37 and 296 of Human ST14|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29764 targets ST14 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-29764 immunogen is recombinant protein fragment corresponding to a region within amino acids 37 and 296 of Human ST14.
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Epithin; epithin); HAI; Matriptase; matriptase/MT-SP1; Membrane-type serine protease 1; MT-SP1; MTSP1; Prostamin; protease, serine, 14 (epithin); PRSS14; Serine protease 14; Serine protease TADG-15; SNC19; suppression of tumorigenicity 14 (colon carcinoma; suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin); Suppressor of tumorigenicity 14 protein; Suppressor of tumorigenicity 14 protein homolog; TADG15; TMPRSS14; tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein
Gene Aliases: ARCI11; Epithin; HAI; matriptase; mCAP3; MT-SP1; MTSP1; PRSS14; SNC19; ST14; TADG15; TMPRSS14
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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