|ChIP assay (ChIP)||5 ug/ml|
|ELISA (ELISA)||Assay Dependent|
|Gel Shift (GS)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20-1:200|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1:250|
|Gel Shift (GS)||See 1 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunohistochemistry - Free Floating (IHC (Free))||See 1 publications below|
|Western Blot (WB)||See 4 publications below|
|Immunoprecipitation (IP)||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Virus , Bovine , Human , Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||A peptide corresponding to the unique carboxy-terminus of murine STAT5b coupled to a protein carrier.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B
Gene Aliases: STAT5; STAT5B
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