|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 16 amino acid peptide from internal region of human STX1A / Syntaxin 1A.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HPC-1; Neuron-specific antigen HPC-1; p35-1; STX1; STX1A; SYN1a; Syntaxin 1A; Syntaxin 1A (brain); Syntaxin-1A
Gene Aliases: HPC-1; P35-1; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623
Entrez Gene ID: (Human) 6804
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