|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Western Blot (WB)||0.25-0.5 µg/ml|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (121 KYPFREHLLQKKE 133) of SUCNR1/GPR91 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
SUCNR1 is a 330 amino acid containing membrane receptor, belonging to the G-protein coupled receptor 1 family, characterized by an extracellular N terminus, seven transmembrane regions, and an intracellular C terminus and playing a role in cell communication. SUCNR1 a receptor for the citric acid cycle intermediate succinate, functions in establishing a neovascular network during development and in response to injury. SUCNR1, in response to increased succinate levels, regulates the production of numerous angiogenic factors including VEGF and may be involved in the modulation of platelet function. It is known to play an essential role in proliferative ischemic retinopathy and is an attractive target for treating diseases such as diabetic retinopathy that stem from aberrant neovascularization in the mature retina. Expression of SUCNR1 is common in kidney and in some other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein-coupled receptor 91; G-protein coupled receptor 91; GPR91; P2Y purinoceptor 1; P2Y purinoceptor 1-like; Succinate receptor 1
Gene Aliases: GPR91; SUCNR1
UniProt ID: (Human) Q9BXA5
Entrez Gene ID: (Human) 56670
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.