|Western Blot (WB)||1-3 µg/ml|
|Western Blot (WB)||See 11 publications below|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Dog, Guinea pig, Mouse, Rabbit|
|Published species reactivity||Dog , Rabbit , Human , Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified rabbit sarcoplasmic reticulum membrane vesicles.|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA3-932 detects sarcalumenin from canine, guinea pig, mouse and rabbit tissues. This antibody specifically detects sarcalumenin and the 53 kDa glycoprotein splice variant.
MA3-932 has been successfully used in Western blot. By Western blot, this antibody detects a 53 kDa and a 160 kDa protein representing the glycoprotein and sarcalumenin, respectively, in rabbit skeletal muscle extracts.
The MA3-932 antigen is purified rabbit sarcoplasmic reticulum membrane vesicles.
Sarcalumenin is a 160 kDa acidic calcium binding glycoprotein found to reside at the inner membrane of the sarcoplasmic reticulum in a calcium dependent manner. The gene encoding sarcalumenin also encodes an alternate splice variant, a 53 kDa glycoprotein which co-localizes with sarcalumenin.
These two proteins are found in the longitudinal sarcoplasmic reticulum and the nonjunctional membranes of the terminal cisternae. They have been observed to co-localize with calcium-ATPase suggesting that they are involved in calcium transport and sequestration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Sarcalumenin; sarcolumenin; sarcoplasmic reticulum glycoprotein; SRL
Gene Aliases: 9830004M20Rik; AW108387; Sar; SRL
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