|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 341 and 399 of Sec62|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Contains||0.025% ProClin 300|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dtrp1; hTP-1; HTP1; membrane protein SEC62, S.cerevisiae, homolog of; SEC62; SEC62 homolog; SEC62 homolog S. cerevisiae; SEC62 preprotein translocation factor; TLOC1; TP-1; Translocation protein 1; Translocation protein SEC62
Gene Aliases: Dtrp1; HTP1; SEC62; TLOC1; TP-1
UniProt ID: (Human) Q99442
Entrez Gene ID: (Human) 7095
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