|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 243 and 487 of Human Sec8|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31027 targets Sec8 in IF and IHC (P) applications and shows reactivity with Human samples.
The PA5-31027 immunogen is recombinant fragment corresponding to a region within amino acids 243 and 487 of Human Sec8.
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exocyst complex component 4; Exocyst complex component Sec8; REC8; SEC8; SEC8-like 1; SEC8L1; Sec8p
Gene Aliases: EXOC4; KIAA1699; SEC8; SEC8L1; Sec8p
UniProt ID: (Human) Q96A65
Entrez Gene ID: (Human) 60412
Molecular Function: membrane traffic protein
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