|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 175 of Human Septin 2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 40% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27485 targets Septin 2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27485 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 175 of Human Septin 2.
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: developmentally down-regulated 5; DIFF6; hNedd5; NEDD-5; NEDD5; neural precursor cell expressed; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; Pnutl3; Septin-2
Gene Aliases: DIFF6; hNedd5; KIAA0158; NEDD-5; NEDD5; Pnutl3; SEPT2
UniProt ID: (Human) Q15019
Entrez Gene ID: (Human) 4735
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