|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS/0.1N acetic acid with 0.1% BSA|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody does not react with rat, bovine, chicken or zebrafish samples.
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina (1,2). Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AA-NAT; Aralkylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Gene Aliases: AANAT; DSPS; SNAT
UniProt ID: (Human) Q16613
Entrez Gene ID: (Human) 15
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