|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Full-length recombinant sphingomyelin synthase r fusion protein.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ceramide phosphoethanolamine synthase; CPE synthase; epididymis luminal protein 177; epididymis secretory sperm binding protein Li 181mP; FLJ25082; HEL-S-181mP; RP11-487I5.5; SAM domain-containing protein 8; SMSr; sphingomyelin synthase related; Sphingomyelin synthase-related protein 1; Sterile alpha motif domain-containing protein 8
Gene Aliases: HEL-177; SAMD8; SMSr
UniProt ID: (Human) Q96LT4
Entrez Gene ID: (Human) 142891
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