|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the N-terminal extension of Sphingosine Kinase 2-L.|
|Purification||Antigen affinity chromatography|
|Contains||0.08% sodium azide|
|Storage conditions||-80° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is Jurkat cell lysate.
Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SK 2; Sphingosine kinase 2; sphingosine kinase type 2
Gene Aliases: SK 2; SK-2; SPHK2; SPK 2; SPK-2
UniProt ID: (Human) Q9NRA0
Entrez Gene ID: (Human) 56848
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