|Western Blot (WB)||3-5 µg/ml|
|Tested Species reactivity||Bovine, Dog, Horse, Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (23 FYDLDSCKHSSYPDSEGA 40) of Spi-B protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Transcription factor Spi-B belongs to the ETS family and contains one ETS DNA-binding domain. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression, thus maintains activity of germinal center and memory B cells by direct repression of major plasma cell factors and thereby plasma cell differentiation. It is reported that Spi-B regulates Progressive multifocal leukoencephalopathy (PML) causing JCVirus gene expression, and may play an important role in JCV activity in the immune and nervous systems. It is also reported Spi-B is expressed in various murine and hematopoietic lines except T lymphoid lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ets transcription factor Spi-B; Spi-1/PU.1 related; SPI-B; Spi-B transcription factor (Spi-1/PU.1 related); Transcription factor Spi-B
Gene Aliases: B42b-like; BOS_17804; SPI-B; SPIB
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