|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 1 and 43 of Human Syntaxin 1a|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28431 targets Syntaxin 1a in WB applications and shows reactivity with Human samples.
The PA5-28431 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 43 of Human Syntaxin 1a.
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HPC-1; Neuron-specific antigen HPC-1; P35-1; STX1; SYN1A; syntaxin 1A (brain); Syntaxin-1A
Gene Aliases: HPC-1; P35-1; STX1; STX1A; SYN1A
UniProt ID: (Human) Q16623
Entrez Gene ID: (Human) 6804
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