|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide near C-terminus of human synuclein-alpha|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
A suggested positive control is brain (posterior cingulated gyrus) tissue.
Synuclein alpha is a protein of 140 amino acids and a member of the synuclein family, which includes three known proteins: alpha-synuclein, beta-synuclein and gamma-synuclein. They are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The alpha- and beta-synucleins are found primarily in brain tissue where they are seen mainly in presynaptic terminals. It may be implicated in the formation of Lewy bodies and the selective degeneration of neurons in sporadic Parkinson and quote;s disease and Lewy body dementia. This antibody is specific for alpha-synuclein and does not cross react with beta-synuclein and will be useful for stuides for he localization and detection of alpha-synuclein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: NACP; PARK1; PARK4; PD1; SNCA
UniProt ID: (Human) P37840
Entrez Gene ID: (Human) 6622
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