|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Dog, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 50-100 of human TAB3.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
TAB3, a member of RNA polymerase beta chain family is a 712 aa, intracellular protein that acts as adaptors linking TAK1 binding proteins. This protein is known to function redundantly as mediator of TAK1 activation in response to various stimuli and is critical for both IL-1 and TNF-induced activation of the NF-kB signal transduction pathway. When overexpressed, TAB3 activates both NF-kB and AP-1 transcription factors. When stimulated by the pro-inflammatory cytokines, protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complex. It is also known to function as DNA-dependent RNA polymerase catalyzing the transcription of DNA into RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mitogen activated protein kinase kinase kinase 7 interacting protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
Gene Aliases: 4921526G09Rik; Kiaa4135; MAP3K7IP3; mKIAA4135; NAP1; TAB3
Molecular Function: transcription factor
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.