|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 514 and 577 of Human TBL1X|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28644 targets TBL1X in WB applications and shows reactivity with Human samples.
The PA5-28644 immunogen is synthetic peptide corresponding to a region within amino acids 514 and 577 of Human TBL1X.
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EBI; F-box-like/WD repeat-containing protein TBL1X; SMAP55; TBL1; Transducin beta-like protein 1X; transducin-beta-like protein 1; Transducin-beta-like protein 1, X-linked; X-linked
Gene Aliases: EBI; SMAP55; TBL1; TBL1X
UniProt ID: (Human) O60907
Entrez Gene ID: (Human) 6907
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