|Immunohistochemistry (Paraffin) (IHC (P))||Assay-dependent|
|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||synthetic peptide CINFTRVKNNQPAKYPL, corresponding to amino acids 481-497 of Human TEM8.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-91702 detects TEM8 from human samples.
MA1-91702 has been successfully used in Western blot applications.
The MA1-91702 immunogen is: Synthetic peptide: CINFTRVKNNQPAKYPL, corresponding to amino acids 481-497 of Human TEM8.
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2310008J16Rik; 2810405N18Rik; Anthrax toxin receptor 1; ATR; FLJ10601; FLJ11298; FLJ21776; TEM8; Tumor endothelial marker 8
Gene Aliases: ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2
Entrez Gene ID: (Human) 84168
Molecular Function: receptor
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