|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 334 and 396 of Human TFB2M|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28638 targets TFB2M in WB applications and shows reactivity with Human samples.
The PA5-28638 immunogen is synthetic peptide corresponding to a region within amino acids 334 and 396 of Human TFB2M.
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dimethyladenosine transferase 2; Dimethyladenosine transferase 2, mitochondrial; h-mtTFB; h-mtTFB2; HCV NS5A-transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; Hkp1; hTFB2M; mitochondrial; mitochondrial 12S rRNA dimethylase; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; N'-adenosyl(rRNA) dimethyltransferase 2; S-adenosylmethionine-6-N'; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
Gene Aliases: Hkp1; mtTFB2; NS5ATP5; TFB2M
UniProt ID: (Human) Q9H5Q4
Entrez Gene ID: (Human) 64216
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