|ELISA (ELISA)||2 - 4 µg/ml|
|Inhibition Assays (IA)||0.3 - 1 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
|Blocking Assay (BLOCK)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human protein expressed in CHO cells.|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-24734 detects TGF beta 1 from human samples.
MA1-24734 has been successfully used in inhibition assay, ELISA, and Western blot procedures. By ELISA, the antibody shows less than 5% cross-reactivity with TGF-beta 1.2 and less than 1% cross reactivity with TGF beta 2, TGF beta 3, and TGF beta 5.
The MA1-24734 immunogen is recombinant, full length human protein expressed in CHO cells.
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Transforming Growth Factor Beta 1 is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues, release transforming growth factors; and essentially all cells possess a specific TGF beta 1 receptor. The multi-modal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta 1 whereas hepatocytes, T and B lymphocytes, keratinocytes and many epithelial cells are inhibited by the peptide. TGF beta 1 interacts with Epidermal Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor, and IL2 either by enhancing or antagonizing their characteristic actions. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CED; DPD1; latency-associated peptide; prepro-transforming growth factor beta-1; TGF-beta-1; TGFB; TGFbeta; Transforming growth factor beta-1
Gene Aliases: CED; DPD1; LAP; TGFB; TGFB1; TGFbeta
UniProt ID: (Human) P01137
Entrez Gene ID: (Human) 7040
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.