|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 208-237 amino acids from the central region of human TGIF|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with chicken and mouse based on sequence homology.
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
Protein Aliases: 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1; TALE homeobox TG-interacting factor; TGFB-induced factor homeobox 1; TGIF; transforming growth factor-beta-induced factor
Gene Aliases: HPE4; TGIF; TGIF1
UniProt ID: (Human) Q15583
Entrez Gene ID: (Human) 7050