|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
|Immunohistochemistry (IHC)||See 1 publications below|
|Tested Species reactivity||Dog, Human|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Clone||2386 (G10 / F11)|
|Immunogen||Synthetic peptide - amino acids 31-50 of Human Thyroid Hormone Receptor beta|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C, do not freeze|
MA1-91680 detects THRB from human, canine samples.
MA1-91680 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The MA1-91680 immunogen is a synthetic peptide corresponding to amino acids 31-50 of Human Thyroid Hormone Receptor beta.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-erbA-2; c-erbA-beta; ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; THR1; THRB1; THRB2; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta; thyroid hormone receptor beta1; thyroid hormone receptor beta2; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Gene Aliases: C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR; THR1; THRB; THRB1; THRB2
UniProt ID: (Human) P10828
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