|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 337 of Human TIE2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28582 targets TIE2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28582 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 337 of Human TIE2.
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Angiopoietin-1 receptor; CD202B; Endothelial tyrosine kinase; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK tyrosine kinase, endothelial; TIE-2; TIE2; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protei; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1
Gene Aliases: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1
UniProt ID: (Human) D3DRK5
Entrez Gene ID: (Human) 7010
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