|Flow Cytometry (Flow)||1 ug /10^6 cells|
|Immunohistochemistry (IHC)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Immunogen||Murine T cell clone AE7 cells|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-17956 targets TIM3 in FACS and IHC applications and shows reactivity with Mouse samples.
The MA5-17956 immunogen is mouse T cell clone AE7 cells.
HAVCR2 is a 281 A.A Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 plays an important role in the regulation of macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ14428; HAVcr-2; HAVCR2; hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2 homolog; kidney injury molecule 4; KIM-3; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM-3; TIMD-3; TIMD3
Gene Aliases: Havcr2; TIM-3; Tim3; Timd3
UniProt ID: (Mouse) Q8VIM0
Entrez Gene ID: (Mouse) 171285
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