|Immunocytochemistry (ICC)||Assay Dependent|
|Western Blot (WB)||2-5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to 15 residues near the N-terminus of human TLR4.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is placenta, spleen or peripheral blood leukocytes.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription
factors such as Protein Kinase C (PKC) á/â and NF- êB (4-6). Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
Protein Aliases: ARMD10; CD284; homolog of Drosophila toll; hToll; TLR-4; TOLL; Toll-like Receptor 4
Gene Aliases: ARMD10; CD284; TLR-4; TLR4; TOLL
UniProt ID: (Human) O00206
Entrez Gene ID: (Human) 7099