|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from the 5th cytoplasmic loop of human transmembrane channel-like protein 8|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Glycerol (1:1) may be added for additional stability.
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epidermodysplasia verruciformis 2; Epidermodysplasia verruciformis protein 2; EVER2; EVIN2; TMC8; transmembrane channel-like 8; Transmembrane channel-like protein 8
Gene Aliases: EV2; EVER2; EVIN2; TMC8
UniProt ID: (Human) Q8IU68
Entrez Gene ID: (Human) 147138
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