|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 195 of Human TMS1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27715 targets TMS1 in WB applications and shows reactivity with Human samples.
The PA5-27715 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 195 of Human TMS1.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptosis-associated speck-like protein containing a CARD; CARD5; Caspase recruitment domain-containing protein 5; hASC; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1; TMS; TMS-1; TMS1
Gene Aliases: ASC; CARD5; PYCARD; TMS; TMS-1; TMS1
UniProt ID: (Human) Q9ULZ3
Entrez Gene ID: (Human) 29108
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