|Immunocytochemistry (ICC)||25 ug/ml|
|Immunofluorescence (IF)||25 ug/ml|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide near the center of human TRIM24|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is EL4 cell lysate.
PA5-34561 can be used with blocking peptide PEP-1604.
TRIM24 (TIF1), a member of the tripartite motif (TRIM) family, plays a role in the regulation of cell proliferation and apoptosis. TRIM24 localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. TIF1 mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors. Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ab2-427; E3 ubiquitin-protein ligase TRIM24; hTIF1; PTC6; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; RNF82; TIF1-alpha; TIF1A; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; transcriptional intermediary factor 1, alpha; TRIM24; Tripartite motif containing 24; tripartite motif-containing 24; Tripartite motif-containing protein 24
Gene Aliases: A130082H20Rik; AI447469; D430004I05Rik; hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; TRIM24
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