|Immunocytochemistry (ICC)||20 µg/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Western Blot (WB)||1 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 15 amino acid peptide near the center of human TRIP6.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is EL4 cell lysate.
PA5-21040 can be used with blocking peptide PEP-1154.
TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a PDZ-binding motif, a Crk SH2-binding motif and/or other protein interacting domains. TRIP6 regulates NF-kappa-B activation and interacts with RICK and TRAF2, proteins that are involved in TNF signaling. TRIP6 antagonizes Fas-induced apoptosis and promotes Fas-mediated cell migration in apoptosis-resistant glioma cells via Src-dependent phosphorylation of TRIP6 at Tyr-55.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: OIP-1; OPA-interacting protein 1; tcag7.1300, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1; thyroid hormone receptor interacting protein 6; Thyroid receptor-interacting protein 6; TR-interacting protein 6; TRIP-6; ZRP-1; zyxin related protein 1; Zyxin-related protein 1
Gene Aliases: OIP-1; OIP1; TRIP-6; TRIP6; TRIP6i2; ZRP-1; Zrp1
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