|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from aa region 750-800 of rat TRPC3 conjugated to an immunogenic carrier protein was used as the antigen|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Protein Aliases: capacitative calcium channel TRPC7; ion channel protein; short transient receptor potential channel 3; short transient receptor potential channel 6; short transient receptor potential channel 7; transient receptor potential cation channel subfamily C member 3; transient receptor protein 6; trp-related protein 3; Trpc3; Trpc6; Trpc7
Gene Aliases: TrpC3c; Trrp3; Trrp6