|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from the 1t cytoplasmic domain of mouse TRPV4 conjugated to an immunogenic carrier protein|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. Belongs to the transient receptor family, TrpV subfamily. Contains 3 ANK repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; Transient receptor potential protein 12; TRP12; TrpV4; trpv4 channel; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
Gene Aliases: 0610033B08Rik; OTRPC4; Trp12; Trpv4; VR-OAC; VRL-2; Vrl2; VROAC
UniProt ID: (Mouse) Q9EPK8
Entrez Gene ID: (Mouse) 63873
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