|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human TSC22D1|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
TSC22 domain family protein, or TSC22, is a transcription factor that belongs to the large family of early response genes. This transcriptional repressor is known to act on the C-type natriuretic peptide (CNP) promoter. TSC22 belongs to the TSC-22/Dip/Bun family and is an intracellular protein that may be found in the cytoplasm or nucleus. This transcription factor is known to regulate cell growth, differentiation and cell death and is involved in modulating the transcriptional activity of Smad3 and Smad4. This protein is ubiquitously expressed in most tissues and widely in both fetal and adult tissues. It is generally expressed in aortic endothelial cells, and induced by cytokines, including TGFB. These proteins may be possible therapeutic targets of leukemia and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cerebral protein 2; Ptg-2; Regulatory protein TSC-22; regulatory protein Tsc22; RP11-269C23.2; TGFB-stimulated clone 22 homolog; TGFB1I4; TGFbeta-stimulated clone 22; transcriptional regulator TSC-22; transforming growth factor beta 1 induced transcript 4; Transforming growth factor beta stimulated clone 22; Transforming growth factor beta-1-induced transcript 4 protein; transforming growth factor beta-stimulated protein TSC-22; TSC22; TSC22 domain family protein 1; TSC22 domain family, member 1; TSC22-related inducible leucine zipper 1b
Gene Aliases: AA589566; AW105905; Egr5; hucep-2; KIAA1994; Ptg-2; TGFB1I4; Tilz1b; TS22A; Tsc; TSC-22; TSC22; TSC22D1
Molecular Function: transcription factor
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