|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse|
|Storage buffer||tissue culture supernatant|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
Clone 373E1 is specific for the keratan sulfate bearing molecular complex.
Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at room temperature for 20 min. Recommended positive control: papillary thyroid carcinoma.
Papillary carcinoma is by far the most frequent malignant tumor of the thyroid with a threefold prevelance in females. Studies have shown that 100% of malignant thyroid lesions were found to contain the keratan sulfate (KS) bearing molecules, while these were virtually absent from benign tissues and other thyroid tumors, with the exception of 21% of follicular carcinoma cases analyzed.
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