|Immunohistochemistry (Paraffin) (IHC (P))||1:40|
|Immunohistochemistry (IHC)||See 4 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Lysate of the human histiocytic leukemia cell line U937|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-12433 targets Topoisomerase II alpha in IHC (P) applications and shows reactivity with Human samples.
The MA5-12433 immunogen is lysate of the human histiocytic leukemia cell line U937.
Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor cells.
Protein Aliases: 170 kD; alpha isozyme; DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; OTTHUMP00000207108; topoisomerase (DNA) II alpha 170kDa
Gene Aliases: TOP2; TOP2A; TP2A
UniProt ID: (Human) P11388
Entrez Gene ID: (Human) 7153