|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (230 KLQIGLEMKNGISQSKERKA 249) of Trace Amine Associated Receptor 1 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
TAAR1 is a 339 amino acid novel membrane protein belonging to the G protein-coupled receptor family and is activated by a broad range of monoamines and amphetamine-related psychostimulants (biogenic amines). It has two N-glycosylation sites at its N terminus and several potential protein kinase sites at its C terminus, including two serines and a single disulfide bridge. It shows lower cAMP accumulation in response to octopamine, tryptamine, dopamine and unresponsive to the classical biogenic amines norepinephrine, serotonin, and histamine. It is also known to have a chemosensory function distinct from odorant receptors and is involved in functional regulation of DAT and is a potentially important target for therapeutics for methamphetamine addiction. Recent studies demonstrated wide distribution of TAAR1 in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RP11-295F4.9; TA1; TaR-1; TAR1; trace amine receptor 1; Trace amine-associated receptor 1; TRAR1
Gene Aliases: TA1; TAAR1; TAR1; TRAR1
UniProt ID: (Human) Q96RJ0
Entrez Gene ID: (Human) 134864
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