|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to human Trag-3.|
|Purification||Antigen affinity chromatography|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This protein is expressed in various tumor cell lines including carcinomas, myeloid or lymphoid malignancies, melanomas or prostate cancer. It is also weakly expressed in kidney and overexpressed in taxol-resistant breast cancer line MDA 435(TR) or the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) or 8226/MDR(10)V.1.
The expression of the cancer-testis antigen Taxol resistanceassociated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxolresistant breast cancer line MDA 435(TR) and the doxorubicinresistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR (10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cancer/testis antigen 24.2; Chondrosarcoma-associated gene 2/3 protein; CSAG family, member 3A; CSAG3B; CT24.2; MGC149851; MGC149852; taxol resistance associated gene 3; Taxol-resistant-associated gene 3 protein; TRAG-3; TRAG3
Gene Aliases: CSAG2; CSAG3; CSAG3A; CT24.2; TRAG3
UniProt ID: (Human) Q9Y5P2
Entrez Gene ID: (Human) 389903
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