|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Immunohistochemistry (IHC)||See 2 publications below|
|Western Blot (WB)||See 3 publications below|
|Tested Species reactivity||Human, Rat|
|Published species reactivity||Rat Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant, full length human protein.|
|Storage conditions||4° C, do not freeze|
MA1-26624 detects E2F4 from human and rat samples.
MA1-26624 has been successfully used in immunohistochemistry (paraffin) procedures.
The MA1-26624 immunogen is recombinant, full length human protein.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E2F transcription factor 4, p107/p130-binding; E2F-4; p107/p130-binding protein; Transcription factor E2F4
Gene Aliases: E2F-4; E2F4
UniProt ID: (Human) Q16254
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