|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1-2 µg/ml|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||2 µg/ml|
|Immunohistochemistry (IHC)||See 20 publications below|
|Immunocytochemistry (ICC)||See 8 publications below|
|Western Blot (WB)||See 34 publications below|
|Immunoprecipitation (IP)||See 4 publications below|
|ELISA (ELISA)||See 4 publications below|
|Blocking Assay (BLOCK)||See 1 publications below|
|Tested Species reactivity||Dog, Guinea pig, Human, Rabbit|
|Published species reactivity||Dog , Rat , Pig , Non-human primate , Hamster , Human , Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified guinea pig liver TGase II|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-12736 targets Transglutaminase II in IF, IHC (P), IP, and WB applications and shows reactivity with Canine, Guinea Pig, Human, and Rabbit samples.
The MA5-12736 immunogen is purified guinea pig liver TGase II.
Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Protein-glutamine gamma-glutamyltransferase 2; protein-glutamine-gamma-glutamyltransferase; TG(C); TGase C; TGase H; TGase-2; TGase-H; Tissue transglutaminase; transglutaminase 2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Transglutaminase C; Transglutaminase H; Transglutaminase-2
Gene Aliases: TG(C); TGC; TGM2
UniProt ID: (Human) P21980
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