|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 307 and 528 of Human Tyrosyl tRNA synthetase|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27434 targets Tyrosyl tRNA synthetase in IF and WB applications and shows reactivity with Human samples.
The PA5-27434 immunogen is recombinant fragment corresponding to a region within amino acids 307 and 528 of Human Tyrosyl tRNA synthetase.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CMTDIC; cytoplasmic; tyrosine tRNA ligase 1; tyrosine tRNA ligase 1, cytoplasmic; tyrosine--tRNA ligase; Tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; Tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; TYRRS; YRS; YTS
Gene Aliases: AL024047; AU018965; CMTDIC; TYRRS; YARS; YRS; YTS
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