|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Mouse, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 106 and 297 of Human UBXN1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31809 targets UBXN1 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-31809 immunogen is recombinant protein fragment corresponding to a region within amino acids 106 and 297 of Human UBXN1.
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.
Protein Aliases: 2B28; mY33K; Protein 2B28; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; UBXD10
Gene Aliases: 2B28; 4930455J02Rik; D19Ertd721e; SAKS1; T25529; UBXD10; UBXN1