|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 1058-1087 amino acids from the C-terminal region of human USP8 (UBPY)|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with mouse based on sequence homology.
USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 8; hUBPy; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; Ubiquitin thiolesterase 8; Ubiquitin-specific processing protease 8; Ubiquitin-specific-processing protease 8
Gene Aliases: HumORF8; KIAA0055; SPG59; UBPY; USP8
UniProt ID: (Human) P40818
Entrez Gene ID: (Human) 9101
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