|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Peptide with sequence C-DNSEAYDELVPASLT, from the internal region of UBN1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
This antibody is predicted to react with mouse, rat, dog, pig, cow and zebrafish based on sequence homology.
Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIRA-binding protein; Protein VT4; ubinuclein 1; Ubinuclein-1; Ubinuclein-2; Ubiquitously expressed nuclear protein; UBN1; UBN2; VT; VT4
Gene Aliases: KIAA2030; UBN1; UBN2; VT; VT4
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