|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||3-5 µg/10^6 cells|
|Immunocytochemistry (ICC)||2 µg/ml|
|Immunofluorescence (IF)||2 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||1:20-1:100|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1-3 µg/ml|
|Western Blot (WB)||See 4 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunoprecipitation (IP)||See 1 publications below|
|Immunofluorescence (IF)||See 1 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Yeast , Mouse Human|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Recombinant protein derived from an internal region of human ubiquilin.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
Dsk2 increases the half-life of proteins destined to be degraded by the proteasome, and may modulate proteasome-mediated protein degradation. The Dsk2 protein binds UBE3A and BTRC, and interacts with the 19S proteasome subunit. In the cytoplasm, Dsk2 colocalizes with the proteasome; it is also associated with fibers in mitotic cells in the nucleus. Dsk2 is highly expressed in mitotic cells from metaphase to telophase, while expression in non-mitotic cells is very low.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Chap1; DSK2 homolog; hPLIC-2; HRIHFB2157; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Protein linking IAP with cytoskeleton-2; Ubiquilin 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2; Ubiquitin-related protein
Gene Aliases: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; Plic-2; PLIC2; UBQLN2
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