|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 265 and 327 of Human VPS26|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28404 targets VPS26 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28404 immunogen is synthetic peptide corresponding to a region within amino acids 265 and 327 of Human VPS26.
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein Aliases: HB58; Hbeta58; hVPS26; PEP8A; vacuolar protein sorting 26 homolog A; Vacuolar protein sorting-associated protein 26A; Vesicle protein sorting 26A; VPS26; VPS26 retromer complex comonent A; VPS26 retromer complex component A
Gene Aliases: HB58; Hbeta58; PEP8A; VPS26; VPS26A
UniProt ID: (Human) O75436
Entrez Gene ID: (Human) 9559
Molecular Function: membrane traffic protein