|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||5 ug/ml|
|Western Blot (WB)||0.5 µg/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid peptide near the carboxy terminus of human VPS39.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is rat liver tissue lysate.
PA5-21104 can be used with blocking peptide PEP-1218.
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6.5.
Protein Aliases: hVam6p; TLP, VAM6, hVam6p; TRAP1-like protein; vacuolar protein sorting 39 homolog; Vam6; Vam6/Vps39-like protein; VPS39 HOPS complex subunit
Gene Aliases: A230065P22Rik; AW743070; hVam6p; KIAA0770; mVam6; Pldn; TLP; VAM6; Vam6P; VPS39