|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 220 of VPS4A (Uniprot ID#Q9UN37)|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-34846 targets VPS4A in WB applications and shows reactivity with Human samples.
The PA5-34846 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 220 of VPS4A (Uniprot ID#Q9UN37).
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hVPS4; Protein SKD2; SKD1; SKD1-homolog; SKD1A; SKD2; vacuolar protein sorting factor 4A; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4; VPS4-1; VPS4A
Gene Aliases: SKD1; SKD1A; SKD2; VPS4; VPS4-1; VPS4A
UniProt ID: (Human) Q9UN37
Entrez Gene ID: (Human) 27183
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