|Immunofluorescence (IF)||0.5-1 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||0.5-1 µg/ml|
|Western Blot (WB)||0.5-1 µg/ml|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1.|
|Storage buffer||whole serum|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-18351 detects VRL-1 from human and rat samples.
PA1-18351 has been successfully used in immunohistochemistry (paraffin), immunofluorescence, and Western blot procedures.
The PA1-18351 immunogen is a synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1, conjugated to KLH.
Reconstitute with 50 ul of distilled water.
VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Osm-9-like TRP channel 2; OTRPC2; Stretch-; Stretch-activated channel 2B; Transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel, subfamily V, member 2; TrpV2; Vanilloid receptor-like protein 1; VRL-1
Gene Aliases: Sac2b; TRPV2; VRL; VRL-1; VRL1
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