|Western Blot (WB)||3.0-5 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (376 QAEEQQKAPGEVMDPREA 394) of Vang-like 1 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Vang-like 1 protein is a novel human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least 7 exons, and encodes a protein with four transmembrane domains and the C-terminal Ser/Thr-X-Val motif. Studies shows that the expression of the protein is significantly up-regulated in gastric cancer cell lines MKN28, MKN74, pancreatic cancer cell lines BxPC-3, PSN-1 and Hs766T. The protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. The protein also serves as a diagnostic marker for hepatocellular carcinoma as well as a potential molecular target for development of novel therapeutic drugs. The pathological role of the protein has been identified in neural tube defects (NTD). Human Vang-like 1 gene maps to chromosome 1p11-p13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KAI1 C-terminal interacting tetraspanin; KAI1 COOH-terminal interacting tetraspanin; KITENIN; Loop-tail protein 2; Loop-tail protein 2 homolog; LPP2; STB2; STBM2; strabismus; Strabismus 2; Van Gogh-like protein 1; vang, van gogh-like 1; vang-like 1 (van gogh, Drosophila); Vang-like protein 1
Gene Aliases: KITENIN; LPP2; STB2; Stbm; STBM2; VANGL1
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