|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Western Blot (WB)||1:1000|
|Western Blot (WB)||See 1 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||synthetic peptide, RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.|
|Storage buffer||whole serum|
|Contains||0.05% sodium azide|
|Storage conditions||-80° C, Avoid Freeze/Thaw Cycles|
PA1-29421 detects Vanilloid receptor 1 from rat, human, mouse, and non-human primate samples.
PA1-29421 has been successfully used in immunocytochemistry, immunohistochemistry (frozen tissue), and Western blot applications. A suggested positive control for this product is VR1 transfected cells. Predicted molecular weight of approximately 100.7 kDa.
The PA1-29421 immunogen is synthetic peptide, RASLDSEESESPPQENSC, corresponding to amino-terminus of Rat VR1, amino acids 4-21.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
Protein Aliases: Capsaicin Receptor; cation channel; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor; VR1
Gene Aliases: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1