|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 371-420 of human X11 gamma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 61 kDa.
Purity is >95% by SDS-PAGE.
Amyloid beta precursor protein ( beta APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The amyloid beta precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid beta precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular beta APP and slowing beta APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of beta APP. Multiple splice varitents of X11 have been identified, including X11 alpha, beta and gamma (also known as Mint 1, 2 and 3, respectively).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapter protein X11gamma; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); Amyloid beta A4 precursor protein-binding family A member 3; APBA3; lin 10; MGC:15815; Mint 3; Mint-3; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11 like 2 protein 2; X11-like 2 protein; X11gamma; X11L2
Gene Aliases: APBA3; MGC:15815; MINT3; X11L2
UniProt ID: (Human) O96018
Entrez Gene ID: (Human) 9546
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